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Objective To study the sensitivity and specificity of parameter Corvis biomechanical index (CBI)— a new biomechanical index of Corvis ST in the diagnosis of keratoconus and evaluate the role of CBI in the diagnosis of keratoconus and the change of biomechanic.Methods A diagnostic trial study was adopted,and 66 eyes from 49 keratoconic patients (keratoconus group) and 91 right eyes from 91 myopic patients (control group) from April in 2018 to August in 2018 in Henan Eye Hospital were enrolled.Pentacam and Corvis ST examinations were performed by the same operator after the basic eye examinations.Using the evaluation of diagnostic test,consistency test,and receiver operating characteristic (ROC) curve analysis,gain the outcome of the sensitivity,specificity,consistency,Youden index,and area under the ROC curve of the parameter CBI.This study protocol was approved by Ethic Committee of Henan Eye Hospital and followed the Declaration of Helsinki.Written informed consent was obtained from each patient prior to any medical examination.Results Sixty eyes were diagnosed as keratoconus by the parameter CBI of Corvis ST.Evaluation of diagnosis test:the sensitivity was 97.0％,and the specificity was 97.8％;consistency check:Kappa =0.948,P＜0.05.ROC curve analysis:the sensitivity was 98.5％,the specificity was 96.8％,Youden index was 96.3％,P＜0.000 1 and AUC was 0.996.Conclusions CBI can separate healthy eyes from keratoconic eyes with highly sensitivity and specificity,which was highly consistency with results of Rabinowitz keratoconus diagnostic criteria.CBI could be used as a new biomechanical indicator for the diagnosis of keratoconus.
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Objective To observe the efficacy and safety of pleural perfusion of recombinant human endostain ( endostar) combined with cisplatin ( DDP) in lung cancer patients with pleural effusion.Methods 80 patients with pleural effusion of lung cancer from January 2011 to December 2014 in our hospital were selected and randomly divided into the treatment group and the control group two groups with 40 cases in each group.Recombinant human endostain and DDP were injected into pleural cavity in the treatment group, the same dose of DDP was injected into the control group.Pleural effusion, KPS, Toxic and the exepress of vascular endothelial growth factor ( VEGF) of pleural effusion were measured before and after treatment. Results After treatment, the clinical efficacy of the observation group (RR), quality of life improvement rate and the level of VEGF in pleural effusion was significantly higher than that in the control group, the difference was statistically significant (P <0.05).The level of VEGF in Bloody pleural effusion was higher than in the non-bloody pleural effusion in the treatment group, there was significant difference (P<0.05).The observation group was higher than that of non hemorrhagic pleural effusion VEGF , the difference was statistically significant ( P <0.05 ) , both of them could lead to the decrease of VEGF level after treatmen, but there was no statistical significance between the two groups.Conclusion Clinical efficacy of intrapleural injection of recombinant human endostatin combined with cisplatin in patients with lung cancer complicated with pleural effusion, low adverse reaction, it is speculated that the recombinant human endostatin can inhibit the growth of tumor and the formation of pleural effusion by inhibiting the expression of VEGF in combination with cisplatin, it could effectively improve the quality of life of patients and prolong life.
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Objective To investigate the CT and MRI manifestations of abdominal inflammatory myofibroblastic tumor (IMT). Methods Imaging and clinical data of 8 cases with IMT which proved by pathology were analyzed retrospectively.5 cases were scaned with contrast medium enhancement CT,and 3 cases with contrast medium enhancement MRI.Results Tumors were located in mesenteric region in 3 cases,in the transverse colon in 1 case,in retroperitoneal space in 1 case,in the small omentum in 1 case, in the omentum in 2 cases.8 cases were all single lesion,5 cases boundaries were demarcated,3 cases boundaries were fuzzy.The maximum diameter of tumors were from 4.6-12.5 cm.The density were uniformin 2 cases,and uneven in 3 cases.3 cases were significantly enhanced on enhanced scanning,2 cases were slight enhanced.1 case was solid soft tissue mass with homogeneous enhancement.2 cases were cystic tumor.The solid part was obvious homogeneous enhancement on enhanced scanning.The cystic areas were not enhancement. Conclusion CT and MRI can clearly demonstrate the location,size,number and the relationship with the surrounding structures of IMT.
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Background Researches showed that femtosecond laser corneal small incision lenticule extraction (SMILE) was used in the correction of myopia and myopic astigmatism due to its fast recovery,good shortterm efficacy and few complications.However,few research focused on its long-term efficacy.Objective Thisstudy was to evaluate the effectiveness,safety,predictability,stability and complications of SMILE.Methods A serial cases-observational study was carried out under the approval of Ethic Committee of Henan Eye Institute and informed consent of patients.Sixty-seven eyes of 34 patients with myopia and myopic astigmatism were included in Henan Eye Institute from January to June 2013.All the patients received SMILE and followed-up for 2-year duration.The uncorrected visual acuity (UCVA),best corrected visual acuity (BCVA),automatic optometry,intraocular pressure and corneal topography were examined before surgery and 1 day,1 week,1 month,3 months,1 year and 2 years after surgery and calculated the spherical equivalent (SE).The long-term efficacy of SMILE included effective index (preoperative BCVA/postoperative UCVA),safety index (postoperative BCVA/ preoperative BCVA),predictability (linear regression analysis between actual SE and attempted SE) and refractive stability (SE changes at postoperative time points).Results The preoperative BCVA was ≥ 20/20 in 60 eyes with the percentage of 89.55％.UCVA≥ 20/20 were found in 61 eyes and 60 eyes in postoperative 3 months and 2 years respectively (91.04％ and 89.55％).The effective index was 1.038±0.182 and 1.029±0.231 in postoperative 3 months and 2 years respectively,showing an insignificant difference between them (t =0.400,P ＞ 0.05).Compared with the preoperative BCVA,8.96％ (6/67) and 10.45％ (7/67) eyes lost 1 line at 3 months and 2 years after surgery,respectively.The safety indexes were 1.141±0.193 and 1.312±0.242 at 3 months and 2 years after surgery,with no significant difference between them (t =0.414,P＞0.05).A linear correlation was found between actual SE and attempted SE both at postoperative 3 months and 2 years,with the linear regression equations of Y=0.897 1X-0.440 8 (R2 =0.914 2,P＜0.05) and Y =0.893 7X-0.382 3 (R2 =0.915 7,P＜0.05),respectively.The SE was (0.013±0.578),(-0.033±0.489),(-0.106±0.508),(-0.103±0.375),(-0.154±0.518) and (-0.147±0.366)D 1 day,1 week,1 month,3 months,1 year and 2 years after surgery,respectively,and there were no significant difference among different time points (F =0.185,P =0.176).Eighteen in the 67 eyes occurred opaque bubble layer after surgery.Diffuse lamellar keratitis appeared in 6 eyes and punctate keratitis was in 2 eyes.These complications were cured 1 month after administration of drugs.Conclusions SMILE is good in effectiveness,safety,predictability and refreactive stability and has fewer complications during 2-year following-up.
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A new method that uses the reduced scattering coefficients (micro'(s)) measured in rat's brain tissue in vivo after administration of hyperosmotic solution by bifurcated fiber optic probe is proposed in this paper. 60 SD rats were divided into three groups by randomization method, and then were treated by 0.9% NaCl, 20% Mannitol and 7.5% NaCl through vena caudalis, respectively. The changes of micro'(s) in every rat's local cortex were observed continuously by a bifurcated fiber optic probe in vivo in a mini-invasive way. No changes of micro'(s) were observed in the control group which was given by 0.9% NaCl, while the micro'(s), relative changes of the 20% mannitol group and 7.5% NaCl group increased by 7.3% +/- 1.7% and 12.8% +/- 2.9%, respectively. The results showed that there were significant differences among the three groups (P < 0.05). The micro'(s) of rat's local cortex observed by bifurcated fiber optic probe can be used for shedding light on the anhydration induced by hyperosmotic solution.
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Animals , Female , Male , Rats , Cerebral Cortex , Mannitol , Pharmacology , Random Allocation , Rats, Sprague-Dawley , Saline Solution, Hypertonic , Pharmacology , Scattering, RadiationABSTRACT
A specifically designed fiber optical spectrum system was applied to measure the hemoglobin oxygen saturation (SO2) of living rat's brain tissue. Collections of in vivo visible absorption spectrum measured by the fiber optical spectrometer at different SO2 as well as their corresponding SO2 values measured by OXImeter were made on a kind of tissue model (i. e. the mixture of Intralipid and blood) and were used as the training data of an artificial neural network (ANN) which, after being trained, can put out SO2 value correctly when an absorption spectrum was put in. The SO2 values of 5 living rats' brain tissue at different depth were obtained, and the experimental error range was +/- 5%. This method is of great significance to important value for monitoring hemoglobin oxygen saturation at various depths in brain minimally invasive surgery.